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A compelling study published in the Pharmacognosy Magazine titled, adds experimental support to the suspicion that fluoride is indeed a brain-damaging substance, also revealing that a natural spice-derived protective agent against the various health effects associated with this compound is available.
The study opens by describing the historical backdrop for concern about fluoride’s significant and wide ranging toxicity:
Fluoride (F) is probably the first inorganic ion which drew attention of the scientific world for its toxic effects and now the F toxicity through drinking water is well-recognized as a global problem. Health effect reports on F exposure also include various cancers, adverse reproductive activities, cardiovascular, and neurological diseases.[1,2]”
The study focused on fluoride induced neurotoxicity, identifying excitoxicity (stimulation of the neuron to the point of death) and oxidative stress as the two main drivers of neurodegeneration. It has been observed that subjects with the condition known as fluorosis, a mottling of tooth enamel caused by excessive exposure to fluoride during tooth development, also have neurodegenerative changes associated with a form of oxidative stress known as lipid peroxidation (rancidity). Excess lipid peroxidation in the brain can lead to a decrease in total brain phospholipid content. Owing to these well-known mechanisms of fluoride associated neurotoxicity and neurodegeneration, the researchers identified the primary polyphenol in the spice turmeric — known as curcumin — as an ideal agent worth testing as a neuroprotective substance. Previous research on curcumin indicates that it is capable of activing as an antioxidant in 3 distinct ways by protecting against: 1) singlet oxygen 2) hyrodxyl radicals and 3) superoxide radical damage. Also, curcumin appears to raise endogenous glutathione production in the brain, a major antioxidant defense system.
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